Mediating Effects of Immunophenotypes on the Causal Relationship of Gut Microbiota and Their Metabolic Pathways With Osteonecrosis: A Mendelian Randomization Analysis
The study findings highlighted the role of the superpathway of sulfate assimilation and cysteine biosynthesis of the gut microbiota in exerting a protective effect against osteonecrosis. This protective effect is substantially mediated by a decrease in the absolute count of CD33<sup>-</sup> HLA DR + Myeloid cell and an increase in T cell % lymphocyte.
Authors
- Hongming Meng (ORCID: https://orcid.org/0000-0002-2670-8918)
- Yuhuan Meng (ORCID: https://orcid.org/0000-0001-7464-3103)
- Minlong Wang (ORCID: https://orcid.org/0000-0001-8631-3523)
- Qing Shen (ORCID: https://orcid.org/0000-0002-6825-2234)
Institutions
- Shaoxing People's Hospital (CN)
Publication Details
- Journal
- Mediators of Inflammation
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1155/mi/9323113
- Primary Topic
- Bone and Joint Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00