Synthesis and Study of the Ru‐Pt Heterometallic Complexes [RuCp(L) (PPh <sub>3</sub> )‐µ‐dmoPTA‐1κ <i>P</i> :2κ <sup>2</sup> ‐ <i>N,N′</i> ‐Pt(κ <sup>2</sup> C <i>,O</i> ‐CH <sub>2</sub> N(CH <sub>3</sub> )CHO)][PtCl <sub>4</sub> ] (L = Cl, PPh <sub>
Complexes [RuCp(PPh<sub>3</sub>)<sub>2</sub>(HdmoPTA)][PtCl<sub>4</sub>] (<b>1</b>), [RuCp(PPh<sub>3</sub>)<sub>2</sub>-µ-dmoPTA-1κ<i>P</i>:2κ<sup>2</sup>-<i>N,N'</i>-Pt(κ<sup>2</sup> <i>C,O</i>-CH<sub>2</sub>N(CH<sub>3</sub>)CHO)][PtCl<sub>4</sub>] (<b>2</b>), [RuClCp(PPh<sub>3</sub>) (HdmoPTA)]<sub>2</sub>[PtCl<sub>4</sub>] (<b>3</b>), and [RuClCp(PPh<sub>3</sub>)-µ-dmoPTA-1κ<i>P</i>:2κ<sup>2</sup>-<i>N,N'</i>-Pt(κ<sup>2</sup> <i>C,O</i>-CH<sub>2</sub>N(CH<sub>3</sub>)CHO)]<sub>2</sub>[PtCl<sub>4</sub>] (<b>4</b>) have been synthesized and characterized by NMR, IR, and crystal structure of <b>2</b> was obtained by single crystal X-Ray diffraction. Antiproliferative activity of <b>1</b> was assessed against six human solid tumor cell lines and compared to cisplatin as a standard, showing GI<sub>50</sub> values in the submicromolar range.
Authors
- José Manuel Padrón (ORCID: https://orcid.org/0000-0001-6268-6552)
- Aday González‐Bakker (ORCID: https://orcid.org/0000-0002-9792-5194)
- Antonio Romerosa (ORCID: https://orcid.org/0000-0002-6285-9262)
- Adrián Puerta
- Franco Scalambra (ORCID: https://orcid.org/0000-0002-5141-0400)
- Andrés Alguacil (ORCID: https://orcid.org/0000-0002-3305-7033)
Institutions
- Universidad de La Laguna (ES)
- University of Almería (ES)
Publication Details
- Journal
- Bioinorganic Chemistry and Applications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1155/bca/4247392
- Primary Topic
- Organometallic Complex Synthesis and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Agencia Canaria de Investigación, Innovación y Sociedad de la Información
- Junta de Andalucía
- Universidad de Almería
- Directorate-General for Employment, Social Affairs and Inclusion