Systemic oxidative stress imbalance in actinic keratosis: Insights from thiol–disulfide homeostasis and ischemia-modified albumin
AK patients show systemic oxidative imbalance, with reduced thiols and elevated IMA, reflecting persistent UV-induced redox stress and protein oxidation. TDH and IMA may have potential utility as systemic indicators of oxidative stress in AK. Limitations include cross-sectional design, modest sample size, and unmeasured confounders. Future longitudinal and interventional studies should assess causality and antioxidant-based therapies.
Authors
- Serkan Akoğul (ORCID: https://orcid.org/0000-0002-0346-4308)
- Tuğba Tehçi (ORCID: https://orcid.org/0000-0002-8588-4292)
- Özcan Erel (ORCID: https://orcid.org/0000-0002-2996-3236)
- Defne Özkoca (ORCID: https://orcid.org/0000-0002-4211-2276)
- Mahmut Sami Metin (ORCID: https://orcid.org/0000-0002-5099-8521)
- Zühal Metin (ORCID: https://orcid.org/0000-0001-9392-0620)
- Salim Neşeli̇oğlu (ORCID: https://orcid.org/0000-0002-0974-5717)
- Abdullah Demirbaş (ORCID: https://orcid.org/0000-0002-3419-9084)
- Esin Diremsizoğlu (ORCID: https://orcid.org/0000-0001-9824-481X)
- İlkay Kolukırık (ORCID: https://orcid.org/0009-0008-8243-1707)
Institutions
- Koç University (TR)
- Ahi Evran University (TR)
- Ankara Yıldırım Beyazıt University (TR)
- Pamukkale University (TR)
- Kocaeli Üniversitesi (TR)
Publication Details
- Journal
- Cutaneous and Ocular Toxicology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1080/15569527.2025.2579933
- Primary Topic
- Nonmelanoma Skin Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00