Construction and evaluation of a combined model of NAA/STZ-induced type 2 diabetes with carotid balloon injury in SD rats
This combined model has stable hyperglycemia, obvious neointimal hyperplasia, rapid modeling and a high success rate (optimal observation window: 2-4 weeks post-VBI). It recapitulates diabetic macroangiopathy pathology and is suitable for investigating therapeutic efficacy and related molecular/cellular mechanisms.
Authors
- Chen Li (ORCID: https://orcid.org/0000-0002-7262-6876)
- Chan Zhu (ORCID: https://orcid.org/0000-0002-4515-4981)
- Qian Zhou (ORCID: https://orcid.org/0000-0001-6957-9821)
- Yanmei Wang
- Qiu Chen (ORCID: https://orcid.org/0009-0001-2216-4968)
- Xiaojing Chenmou
Institutions
- Sichuan University (CN)
- Ya'an Polytechnic College (CN)
- West China Second University Hospital of Sichuan University (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.3389/fendo.2025.1693820
- Primary Topic
- Calpain Protease Function and Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00