Increased spontaneous physical activity in female MEST-deficient mice protects against diet-induced obesity
Mechanistically, our results suggest that MEST directly or indirectly regulates thyroid hormone-responsive genes in the hypothalamus, thereby modulating the neurobiological control of nonexercise activity thermogenesis in Western diet-fed female mice.
Authors
- Robert A. Koza
- Victoria DeMambro (ORCID: https://orcid.org/0000-0002-4557-461X)
- Arturo Hernández (ORCID: https://orcid.org/0000-0002-6314-3987)
- María Martínez (ORCID: https://orcid.org/0000-0003-2180-4537)
- Rea Victoria P. Anunciado‐Koza
Institutions
- Pennington Biomedical Research Center (US)
- Tufts University (US)
- MaineHealth (US)
- University of Maine (US)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.3389/fendo.2025.1680158
- Citations
- 1
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- National Institutes of Health
- Nutrition Obesity Research Center, University of North Carolina
- National Institute of General Medical Sciences