Identification and validation of key mitophagy-related biomarkers in the pathogenesis of proliferative diabetic retinopathy
Integrated bioinformatics and experimental validation suggest that mitophagy contributes to PDR pathogenesis. Five DEMRGs showed up-regulated and immune cell infiltration that may affect the occurrence and PDR development by regulating mitophagy. These findings provide candidate biomarkers and mechanistic insight into PDR.
Authors
- Jieping Zhang (ORCID: https://orcid.org/0000-0003-2559-4151)
- Qingjian Ou (ORCID: https://orcid.org/0000-0002-6881-8680)
- Caixia Jin
- Ling Zhu (ORCID: https://orcid.org/0000-0003-3818-6093)
- Jiahui Jin (ORCID: https://orcid.org/0000-0003-2546-5632)
- Jie Chen (ORCID: https://orcid.org/0000-0002-7773-3160)
- Yifan Liu (ORCID: https://orcid.org/0000-0002-4287-5468)
- Jiao Li (ORCID: https://orcid.org/0000-0001-9446-5076)
- Xueying Wang (ORCID: https://orcid.org/0000-0002-7835-113X)
- Xi Wang (ORCID: https://orcid.org/0000-0002-2885-4388)
- Junfang Zhang (ORCID: https://orcid.org/0009-0009-2002-2649)
- Guo-Tong Xu
- Ye Zhou (ORCID: https://orcid.org/0009-0005-7471-3278)
- Yanlong Bi (ORCID: https://orcid.org/0000-0001-8214-4355)
Institutions
- Tongji University (CN)
- Tongji Hospital (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.3389/fendo.2025.1652898
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00