Passive hydrotherapy preserves cartilage and muscle integrity in a murine osteoarthritis model: potential role of integrin αV/TGF-β mechanotransduction
These findings demonstrate that hydrotherapy confers cartilage-protective benefits comparable to swimming in a mouse model of OA. Possibly through the modulation of mechanosensitive signaling pathways, hydrotherapy may represent a viable, non-pharmacological strategy for delaying OA progression, particularly in individuals with limited capacity for conventional physical exercise.
Authors
- Rong Yang (ORCID: https://orcid.org/0000-0001-8837-0089)
- Yong Huang (ORCID: https://orcid.org/0000-0003-2652-8586)
- Gang Wu (ORCID: https://orcid.org/0000-0001-6558-3508)
- Di Wu (ORCID: https://orcid.org/0000-0003-4430-3006)
- Hao Hu (ORCID: https://orcid.org/0000-0002-4604-6333)
- Duan Xiaofeng
- Wang Songyang
- Feng Ruibing
- Dong Yunxiang
Institutions
- China Three Gorges University (CN)
- Hubei University of Chinese Medicine (CN)
- Hubei Provincial Hospital of Traditional Chinese Medicine (CN)
- Wuhan Sports University (CN)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.3389/fphys.2025.1633618
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00