Melatonin modulates the gene expression of WEE1 kinase and clock genes: a crosstalk between the molecular clocks of the placenta?
We observed rhythmic expression of <i>BMAL1</i>, <i>PER1</i>, <i>PER2</i>, and <i>WEE1</i> in human placental explants, consistent with the temporal patterns detected <i>in silico</i>. Melatonin treatment suppressed the circadian oscillation of <i>BMAL1</i>, <i>PER2</i>, and <i>WEE1</i>. Interestingly, the placenta produced melatonin steadily over 36 hours, and exogenous melatonin did not alter this production.
Authors
- G. Cabello (ORCID: https://orcid.org/0000-0001-5764-944X)
- Kevins Jara-Medina (ORCID: https://orcid.org/0000-0002-5013-896X)
- Constanza Lagunas
- Francisco J. Valenzuela-Melgarejo (ORCID: https://orcid.org/0000-0002-2656-0124)
- Carlos Venegas
- Luis Lillo (ORCID: https://orcid.org/0009-0007-3149-9085)
- Nicole Cueto
Institutions
- University of Bío-Bío (CL)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.3389/fendo.2025.1640635
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.00