Comprehensive dietary patterns explain acquired cystic kidney disease risk through genetic and metabolomic mechanisms
Diets high in fat (cheese, butter, pizza) and sugar (chocolate, sugary drinks) elevated ARC risk, whereas micronutrient- and fiber-rich diets (vegetables, fruit, lean poultry, nuts, eggs) were protective. Key mediators included branched-chain amino acids, IGF-1, and RBC distribution width.
Authors
- Jiayu Liang
- Kai Wu (ORCID: https://orcid.org/0000-0002-5016-0251)
- Qin Cao (ORCID: https://orcid.org/0000-0002-3106-562X)
- Hao Zeng (ORCID: https://orcid.org/0000-0002-1831-3019)
- Fan Zhang (ORCID: https://orcid.org/0000-0003-1608-7764)
- Shengzhuo Liu (ORCID: https://orcid.org/0000-0001-8424-2549)
- Zhihong Liu (ORCID: https://orcid.org/0000-0001-6093-0726)
- Junjie Zhao
- Chenhao Xu (ORCID: https://orcid.org/0000-0002-1489-1970)
- Zheng Wan (ORCID: https://orcid.org/0000-0001-8455-3478)
- Yongquan Tang (ORCID: https://orcid.org/0000-0003-3555-2764)
- Xianding Wang (ORCID: https://orcid.org/0000-0003-0113-0395)
Institutions
- Chinese University of Hong Kong (HK)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- State Key Laboratory of Biotherapy
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-10-29
- DOI
- https://doi.org/10.3389/fnut.2025.1611656
- Primary Topic
- Genetic and Kidney Cyst Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Sichuan University
- Natural Science Foundation of Sichuan Province
- West China Hospital, Sichuan University