The role of the MYL12A liquid-liquid phase separation in neutrophil improves the prognosis of acute respiratory distress syndrome: a multi-omics analysis
This study demonstrates that LLPS dynamically regulates neutrophil migration through MYL12A phosphorylation-dependent phase separation, exerting immunoprotective effect in ARDS. The LLPS status of MYL12A and its activity score may serve as ARDS prognostic biomarkers and offer a novel strategy for developing LLPS-targeted immunomodulatory therapies.
Authors
- Longjie Li (ORCID: https://orcid.org/0000-0001-5866-617X)
- Bing Wan (ORCID: https://orcid.org/0000-0002-8370-2977)
- Zexu Wang
- Wei Qiu (ORCID: https://orcid.org/0000-0002-0880-958X)
- Li Wang (ORCID: https://orcid.org/0000-0002-6785-3548)
- Qian Li (ORCID: https://orcid.org/0000-0003-3186-4445)
- Yongjun Wang (ORCID: https://orcid.org/0000-0001-5876-1775)
- Yufang Guo
Institutions
- Suizhou Central Hospital (CN)
- Nanjing Jiangning Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.3389/fimmu.2025.1662680
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00