Physical capacity modulates intestinal barrier dysfunction in functional disorders: phenotype-specific patterns in fibromyalgia and irritable bowel syndrome
Intestinal barrier dysfunction in FM and IBS displays phenotype-specific patterns and is significantly modulated by PC. These findings support the integration of PC assessment into clinical phenotyping and highlight potential targets for personalized management of chronic overlapping pain syndromes.
Authors
- Claudia Beatrice Bagnato
- Isabella Franco (ORCID: https://orcid.org/0000-0002-3697-0127)
- G. Laselva
- Michele Linsalata (ORCID: https://orcid.org/0000-0001-7350-2544)
- Benedetta D’Attoma (ORCID: https://orcid.org/0000-0002-5416-3521)
- Giuseppe Riezzo (ORCID: https://orcid.org/0000-0002-1800-4830)
- Laura Prospero (ORCID: https://orcid.org/0000-0002-5311-2829)
- Francesco Russo (ORCID: https://orcid.org/0000-0003-0538-6072)
- Maria Notarnicola (ORCID: https://orcid.org/0000-0003-2274-2198)
- Antonella Bianco (ORCID: https://orcid.org/0000-0001-9319-5422)
- Nicola Verrelli
- Marco Grasso (ORCID: https://orcid.org/0000-0001-8643-1490)
- Antonia Ignazzi (ORCID: https://orcid.org/0000-0003-4980-9997)
- Anna Ancona (ORCID: https://orcid.org/0009-0009-7662-1763)
- Francesco Goscilo
Institutions
- Gastroenterology Hospital "Saverio de Bellis" (IT)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.3389/fphys.2025.1695163
- Citations
- 2
- Primary Topic
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Ministero della Salute