Single-cell atlas of human penile corpus cavernosum reveals cellular and functional heterogeneity of aging-related erectile dysfunction

The mild ED phase represents a critical window of cellular functional transition in penile tissue. In ARED, we observed functional dysfunction of EC and SMC, accompanied by changed expression levels of key genes. Concurrently, the pro-inflammatory Macro_CXCL8 exhibited increased proportion in the microenvironment, which may contribute to disease progression. This work not only provides a detailed description of the cellular atlas of the aging penis but also offers new insights into its role in the pathogenesis of ARED and may provide potential targets for the development of new therapies for ARED.

Authors

Institutions

Publication Details

Journal
Frontiers in Endocrinology
Published
2025-10-29
DOI
https://doi.org/10.3389/fendo.2025.1671482
Citations
1
Primary Topic
Sexual function and dysfunction studies
Type
article
Field-Weighted Citation Impact
1.47

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Single-cell atlas of human penile corpus cavernosum reveals cellular and functional heterogeneity of aging-related erectile dysfunction

Hao Bo, Kongrong Xu, Xiaoyan Wang, Ran Li et al.
1 citations
Frontiers in Endocrinology
Sexual function and dysfunction studies
1.47
article

Single-cell atlas of human penile corpus cavernosum reveals cellular and functional heterogeneity of aging-related erectile dysfunction

Hao Bo, Kongrong Xu, Xiaoyan Wang, Ran Li, Jian Cao, Zhizhong Liu, Bailing Zhang, Xueheng Zhao, Jingtao Guo
article en
1 citations

Abstract

The mild ED phase represents a critical window of cellular functional transition in penile tissue. In ARED, we observed functional dysfunction of EC and SMC, accompanied by changed expression levels of key genes. Concurrently, the pro-inflammatory Macro_CXCL8 exhibited increased proportion in the microenvironment, which may contribute to disease progression. This work not only provides a detailed description of the cellular atlas of the aging penis but also offers new insights into its role in the pathogenesis of ARED and may provide potential targets for the development of new therapies for ARED.

Frontiers in EndocrinologyVol. 16
Central South University (CN), Hunan Normal University (CN), Changsha Normal University (CN), Institute for Stem Cell Biology and Regenerative Medicine (IN), Reproductive & Genetic Hospital CITIC-Xiangya (CN), Guangxi Zhuang Autonomous Region Health and Family Planning (CN), Hunan Cancer Hospital (CN), National Engineering Research Center of Human Stem Cells (CN), Guangxi Maternal and Child Health Hospital (CN), University of Chinese Academy of Sciences (CN), Institute of Zoology (CN)
Chinese Academy of Sciences, Institute of Zoology, Chinese Academy of Sciences
Openalex Percentile: Top 14%
Sexual function and dysfunction studies
1.47
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.