Clinical characteristics and prognostic analysis of different fusion gene abnormalities in childhood acute lymphoblastic leukaemia
Fusion gene abnormalities significantly influence the clinical presentation and prognosis of childhood ALL. E2A::PBX1 and TEL::AML1 demonstrate favorable outcomes, whereas BCR::ABL, MLL::AF4 and SIL::TAL1 are associated with unfavorable prognosis. These findings provide valuable insights for risk stratification and treatment optimization in pediatric ALL.
Authors
- Mengmeng Zhao
- Xiaojuan Zhu (ORCID: https://orcid.org/0000-0001-8386-8064)
- Rui Fan (ORCID: https://orcid.org/0000-0003-2593-6596)
- Xi Chen (ORCID: https://orcid.org/0000-0002-9706-3571)
- Bao Liu (ORCID: https://orcid.org/0000-0001-6359-959X)
- Peiling Li (ORCID: https://orcid.org/0000-0002-3732-3802)
- Yanyan Ma
- Yuanfei Wang (ORCID: https://orcid.org/0000-0003-4134-307X)
- Shujun Li (ORCID: https://orcid.org/0000-0002-9724-2553)
- Yunjiao Tian
Institutions
- Xinyang Central Hospital (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.3389/fonc.2025.1616686
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00