Pdgfrα deficiency in islet β-cells up-regulates apoptosis of beta-cells and disturbs glucose metabolism in B6 mice
Our findings demonstrate that PDGFRα plays a critical role in maintaining β-cell function and glucose homeostasis. Loss of PDGFRα impairs β-cell survival and insulin production, likely through the PI3K-Atf5 axis. These insights suggest that targeting β-cell apoptotic pathways, particularly involving Atf5 and its downstream effectors, may offer promising avenues for the prevention and treatment of Type 2 Diabetes.
Authors
- Youjia Hu
- F. Susan Wong (ORCID: https://orcid.org/0000-0002-2812-8845)
- Pai Wang (ORCID: https://orcid.org/0000-0002-7829-8519)
- Juan Huang (ORCID: https://orcid.org/0009-0009-6846-2678)
- Jianlei Gu (ORCID: https://orcid.org/0000-0002-9337-5017)
- Hongyu Zhao (ORCID: https://orcid.org/0000-0003-1195-9607)
- James A. Pearson (ORCID: https://orcid.org/0000-0002-2867-2269)
- Wen Li (ORCID: https://orcid.org/0000-0003-2402-6769)
- Luyao Zhang (ORCID: https://orcid.org/0000-0001-9408-9496)
- Jian Peng (ORCID: https://orcid.org/0000-0003-0991-3896)
- Yanpeng Xing
Institutions
- Central South University (CN)
- Jilin University (CN)
- Yale University (US)
- Yale New Haven Health System (US)
- First Hospital of Jilin University (CN)
- Ministry of Education and Child Care (CA)
- Institute of Infection and Immunity (CA)
- Cardiff University (GB)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.3389/fendo.2025.1630979
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Diabetes Action Research and Education Foundation
- National Institutes of Health
- Medical Research Council