Necrosis by sodium overload-associated genes TRPM4 and SLC9A1: biological roles and clinical implications in breast cancer progression
TRPM4 and SLC9A1 is a novel prognostic biomarker and potential therapeutic target in breast cancer. Dysregulated sodium homeostasis mediated by NECSO-related genes represents a targetable vulnerability in precision oncology.
Authors
- Yanlin Su (ORCID: https://orcid.org/0000-0002-8407-006X)
- Zhuoqi Zhang
- Yaxin Guo (ORCID: https://orcid.org/0000-0002-4690-8212)
- Xianghan Zhang (ORCID: https://orcid.org/0000-0002-4373-0850)
- Yan Zhu (ORCID: https://orcid.org/0000-0001-9620-7505)
- Yu Lu (ORCID: https://orcid.org/0009-0003-8520-4722)
- Hui Pang
Institutions
- Harbin Medical University (CN)
- Capital Medical University (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.3389/fimmu.2025.1623511
- Primary Topic
- Ion Transport and Channel Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00