Exercise reshapes gut microbiota to ameliorate core symptoms in PCOS: molecular mechanisms and therapeutic implications
Exercise remodels the gut microbiota-metabolism-immune network to reverse PCOS pathophysiology. Targeting microbial metabolites (e.g., butyrate, BAs) or their receptors (FXR, GPR43) offers novel therapeutic strategies. Future research must address PCOS heterogeneity and optimize exercise protocols for microbiota-directed precision medicine.
Authors
- Leqin Chen
- Ronghui Wang
- Qianqian Li (ORCID: https://orcid.org/0000-0002-7508-2130)
Institutions
- Taiyuan Normal University (CN)
- Beijing Sport University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.3389/fendo.2025.1652731
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61