NGF/ERK signaling-mediated epigenetic regulation of neuropathic pain in the cerebrospinal fluid-contacting nucleus

This is the first study to identify an NGF/ERK/ acetylated histone H3 (Ac-H3) signaling axis in the CSF-CN as a central mediator of neuropathic pain through epigenetic modulation. Our results suggest that targeting this novel signaling pathway may provide new therapeutic strategies for managing NP.

Authors

Institutions

Publication Details

Journal
Frontiers in Neurology
Published
2025-10-29
DOI
https://doi.org/10.3389/fneur.2025.1641450
Primary Topic
Pain Mechanisms and Treatments
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

NGF/ERK signaling-mediated epigenetic regulation of neuropathic pain in the cerebrospinal fluid-contacting nucleus

Guangling Li, Chao Wang
Frontiers in Neurology
Pain Mechanisms and Treatments
article

NGF/ERK signaling-mediated epigenetic regulation of neuropathic pain in the cerebrospinal fluid-contacting nucleus

Guangling Li, Chao Wang
article en

Abstract

This is the first study to identify an NGF/ERK/ acetylated histone H3 (Ac-H3) signaling axis in the CSF-CN as a central mediator of neuropathic pain through epigenetic modulation. Our results suggest that targeting this novel signaling pathway may provide new therapeutic strategies for managing NP.

Frontiers in NeurologyVol. 16
Jiangnan University (CN), Wuxi Fourth People's Hospital (CN)
Openalex Percentile: Top 61%
Pain Mechanisms and Treatments
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

NGF/ERK signaling-mediated epigenetic regulation of neuropathic pain in the cerebrospinal fluid-contacting nucleus — Guangling Li, Chao Wang · Frontiers in Neurology (2025) | TGRS Research Map | TGRS