Impact of nurse-led intervention on the level of anxiety and depression among chronic kidney disease patients at Bhubaneswar, Odisha, India

<title>Abstract</title> Background Chronic Kidney disease (CKD) patients face ongoing challenges, including lifestyle changes, medication adherence, and managing treatment complexities and complications daily. The aim was to find out the impact of Nurse-led intervention on the level of anxiety and depression among CKD patients. Methods This study was conducted at Institute of Medical Sciences (IMS) and SUM Hospital in Bhubaneswar, Odisha, and focused on CKD patients. The sample consisted of CKD patients aged over 18 years who were proficient in Odia, excluding those with existing mental illness or undergoing psychotherapy. Using block randomization with block sizes of 5 and concealed allocation sequences, participants were distributed to either control or an experimental group.The initial sample size was calculated at 60 participants to accommodate potential dropouts during the study period. Results The Nurse-led intervention helped reduce the anxiety levels among CKD patients at different periods, i.e. baseline, 6th week and 12th week of a follow-up visit for CKD patients, which shows a statistically significant F (2.036) df-29, p &lt; 0.001 and F (26.314) df-2, p &lt; 0.001.Nurse-led intervention on depression scores within experimental, between experimental and control groups at different periods, i.e. baseline, 6th week and 12th week of a follow-up visit for CKD patients, which shows a statistically significant F (22.049) df-29, p &lt; 0.001 and F (75.192) df-2, p &lt; 0.001. Conclusion The nurse-led intervention significantly reduces the score of hospital anxiety and depression scalein CKD patients, highlighting the vital role of nursing care in improving mental health, lifestyle changes and overall wellbeing. Trial registration The clinical trial was registered with India’s Clinical Trial Registry (CTRI/2022/08/044974). Registration Date 260822