Integrating a motor domain enhances disease severity scales in an FTD‐ALS spectrum cohort
CDR + NACC FTLD-M and MIR strongly correlate with objective motor measures. The enhanced scales improve disease severity classification in FTD and ALS. Greater clinical trial efficiency is achieved using these enhanced scales.
Authors
- Kiran Samra (ORCID: https://orcid.org/0000-0002-3105-7099)
- Laura E. Danielian
- Ariana Duckett
- Bryan J. Traynor (ORCID: https://orcid.org/0000-0003-0527-2446)
- Janet E. Crook
- Jennifer Farren
- Sonja W. Scholz (ORCID: https://orcid.org/0000-0002-6623-0429)
- Bradley F. Boeve (ORCID: https://orcid.org/0000-0002-4153-8187)
- Lucy L. Russell
- Tianxia Wu
- Howard J. Rosen (ORCID: https://orcid.org/0000-0001-9281-7402)
- Fiona Lin
- Taryn Haselhuhn
- Allison Snyder
- Marcell Szabo (ORCID: https://orcid.org/0000-0002-1336-1951)
- Justin Kwan (ORCID: https://orcid.org/0000-0003-1558-4451)
- Jonathan D. Rohrer
- K. A. Porter (ORCID: https://orcid.org/0009-0002-3949-7475)
Institutions
- National Institutes of Health (US)
- Mayo Clinic (US)
- Johns Hopkins University (US)
- University of California, San Francisco (US)
- University Medical Center (US)
- University Memory and Aging Center (US)
- National Institute of Neurological Disorders and Stroke (US)
- UK Dementia Research Institute (GB)
- Institute on Aging (US)
- National Institute on Aging (US)
- University College London (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/alz.70786
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Health and Human Services
- National Institutes of Health