APOE4 modulates the association between DTI‐ALPS index and Alzheimer's pathologies
Apolipoprotein E4 (APOE4) status moderates the link between analysis along the perivascular space (ALPS) index and cerebral beta-amyloid. Lower ALPS index is associated with higher beta-amyloid (Aβ) only in APOE4 carriers. No significant moderation by APOE4 on ALPS-tau association was found. ALPS index may offer non-invasive glymphatic marker for beta-amyloid burden.
Authors
- Yu Kyeong Kim (ORCID: https://orcid.org/0000-0002-3282-822X)
- Gijung Jung (ORCID: https://orcid.org/0000-0001-5952-3373)
- Keon Wook Kang (ORCID: https://orcid.org/0000-0003-2622-9017)
- Hyojin Nam (ORCID: https://orcid.org/0000-0003-0456-6100)
- Yun‐Sang Lee (ORCID: https://orcid.org/0000-0003-1640-2090)
- Jae-Woon Ryu
- Min Soo Byun (ORCID: https://orcid.org/0000-0003-3159-4510)
- Chanrim Park
- Hyejin Ahn (ORCID: https://orcid.org/0000-0002-6613-4680)
- Dahyun Yi (ORCID: https://orcid.org/0000-0002-0860-0946)
- Chul‐Ho Sohn (ORCID: https://orcid.org/0000-0003-0039-5746)
- Jun‐Young Lee (ORCID: https://orcid.org/0000-0002-5893-3124)
- Dong Young Lee (ORCID: https://orcid.org/0000-0001-8976-8320)
- Joon Hyung Jung
Institutions
- Seoul National University (KR)
- New Generation University College (ET)
- Seoul National University Hospital (KR)
- SNUH SMG-SNU Boramae Medical Center (KR)
- Chungbuk National University Hospital (KR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/alz.70837
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Seoul National University
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Seoul National University Hospital
- Ministry of Science and ICT, South Korea