Characterizing the Pleiotropic Architecture of Impulsivity and Its Links to Psychopathology and Neurodevelopment

These findings provide new insights into the pleiotropic architecture of impulsivity, its multifaceted biology, and its diverse relationships with mental health. The study underscores the importance of considering impulsivity as a genetically heterogeneous construct and highlights key neurodevelopmental pathways that shape its expression across the lifespan.

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Publication Details

Journal
American Journal of Psychiatry
Published
2025-10-29
DOI
https://doi.org/10.1176/appi.ajp.20240382
Citations
3
Primary Topic
Neurotransmitter Receptor Influence on Behavior
Type
article
Field-Weighted Citation Impact
2.73
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article

Characterizing the Pleiotropic Architecture of Impulsivity and Its Links to Psychopathology and Neurodevelopment

Andrew David Grotzinger, Camille Michèle Williams, Mariela Jennings, Justin D. Tubbs et al.
3 citations
American Journal of Psychiatry
Neurotransmitter Receptor Influence on Behavior
2.73
article

Characterizing the Pleiotropic Architecture of Impulsivity and Its Links to Psychopathology and Neurodevelopment

Andrew David Grotzinger, Camille Michèle Williams, Mariela Jennings, Justin D. Tubbs, Sandra Sanchez‐Roige, Abraham A. Palmer, Karmel W. Choi, Jordan W. Smoller, Lea K. Davis, Travis T. Mallard, Daniel E. Gustavson, Sarah L. Elson, Elliot M. Tucker–Drob, Ge Tian, Armin Raznahan, Margaret L. Westwater, Pierre Fontanillas, Rebecca G. Fortgang, Yingzhe Zhang
article en
3 citations

Abstract

These findings provide new insights into the pleiotropic architecture of impulsivity, its multifaceted biology, and its diverse relationships with mental health. The study underscores the importance of considering impulsivity as a genetically heterogeneous construct and highlights key neurodevelopmental pathways that shape its expression across the lifespan.

American Journal of PsychiatryVol. 183(1)
Broad Institute (US), National Institutes of Health (US), Harvard University (US), University of Colorado Boulder (US), University of California San Diego (US), University of Oxford (GB), Massachusetts General Hospital (US), 23andMe (United States) (US), Institute for Behavioral Medicine (US), The University of Texas at Austin (US), Vanderbilt University Medical Center (US)
Openalex Percentile: Top 9%
Neurotransmitter Receptor Influence on Behavior
2.73
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