Characterizing the Pleiotropic Architecture of Impulsivity and Its Links to Psychopathology and Neurodevelopment
These findings provide new insights into the pleiotropic architecture of impulsivity, its multifaceted biology, and its diverse relationships with mental health. The study underscores the importance of considering impulsivity as a genetically heterogeneous construct and highlights key neurodevelopmental pathways that shape its expression across the lifespan.
Authors
- Andrew David Grotzinger (ORCID: https://orcid.org/0000-0001-7852-9244)
- Camille Michèle Williams (ORCID: https://orcid.org/0000-0002-1471-6566)
- Mariela Jennings
- Justin D. Tubbs (ORCID: https://orcid.org/0000-0002-6671-6816)
- Sandra Sanchez‐Roige (ORCID: https://orcid.org/0000-0001-6137-5699)
- Abraham A. Palmer (ORCID: https://orcid.org/0000-0003-3634-0747)
- Karmel W. Choi (ORCID: https://orcid.org/0000-0002-3914-2431)
- Jordan W. Smoller (ORCID: https://orcid.org/0000-0002-0381-6334)
- Lea K. Davis (ORCID: https://orcid.org/0000-0001-5143-2282)
- Travis T. Mallard (ORCID: https://orcid.org/0000-0002-3265-3001)
- Daniel E. Gustavson (ORCID: https://orcid.org/0000-0002-1470-4928)
- Sarah L. Elson (ORCID: https://orcid.org/0000-0002-3211-3750)
- Elliot M. Tucker–Drob (ORCID: https://orcid.org/0000-0001-5599-6237)
- Ge Tian (ORCID: https://orcid.org/0000-0003-1306-652X)
- Armin Raznahan (ORCID: https://orcid.org/0000-0002-5622-1190)
- Margaret L. Westwater (ORCID: https://orcid.org/0000-0002-2918-0979)
- Pierre Fontanillas (ORCID: https://orcid.org/0000-0002-8944-4454)
- Rebecca G. Fortgang (ORCID: https://orcid.org/0000-0001-5388-3386)
- Yingzhe Zhang (ORCID: https://orcid.org/0000-0001-5610-1159)
Institutions
- Broad Institute (US)
- National Institutes of Health (US)
- Harvard University (US)
- University of Colorado Boulder (US)
- University of California San Diego (US)
- University of Oxford (GB)
- Massachusetts General Hospital (US)
- 23andMe (United States) (US)
- Institute for Behavioral Medicine (US)
- The University of Texas at Austin (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- American Journal of Psychiatry
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1176/appi.ajp.20240382
- Citations
- 3
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 2.73