Population pharmacokinetics of lumefantrine in pregnant and non‐pregnant women with uncomplicated <i>Plasmodium falciparum</i> malaria in Western Kenya
The exposure to lumefantrine was lower in pregnant women, compared to non-pregnant women, with uncomplicated P. falciparum infection. This lower drug exposure might increase the risk of treatment failure with artemether-lumefantrine in pregnant women, especially if susceptibility to either drug is reduced. Continuous assessment and monitoring of the efficacy of artemether-lumefantrine in pregnant women are warranted.
Authors
- Kevin Onyango (ORCID: https://orcid.org/0000-0002-0196-4384)
- Martin O. Ongas (ORCID: https://orcid.org/0000-0001-6838-8417)
- Rashid Aman (ORCID: https://orcid.org/0000-0002-6549-4887)
- Nelly Koskei
- Florence Oloo (ORCID: https://orcid.org/0009-0005-6039-8385)
- Bernhards Ragama Ogutu (ORCID: https://orcid.org/0000-0002-0992-5654)
- Gilbert Kokwaro (ORCID: https://orcid.org/0000-0001-8981-2379)
- Joel Tärning (ORCID: https://orcid.org/0000-0003-4566-4030)
- Junjie Ding (ORCID: https://orcid.org/0000-0002-6429-3178)
- Elizabeth A Juma (ORCID: https://orcid.org/0000-0003-3157-2637)
Institutions
- Strathmore University (KE)
- Mahidol University (TH)
- Kenya Medical Research Institute (KE)
- University of Oxford (GB)
- Mahidol Oxford Tropical Medicine Research Unit (TH)
- African Centre for Technology Studies (KE)
- Infectious Diseases Data Observatory (GB)
Publication Details
- Journal
- British Journal of Clinical Pharmacology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1111/bcp.70318
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00