Using memory recall response time on digital cognitive testing to detect subtle cognitive changes among cognitively unimpaired older adults
We examined recall response time (RT) changes over 7 days of repeated digital learning tasks. RT reveals learning-related changes even after accuracy plateaus. RT correlates with medial temporal tau and is moderated by age for neocortical tau. Digital RT data provide insights beyond accuracy, detecting subtle cognitive changes. RT may serve as a novel digital marker for preclinical Alzheimer's disease.
Authors
- Reisa A. Sperling (ORCID: https://orcid.org/0000-0003-1535-6133)
- Mark A. Dubbelman (ORCID: https://orcid.org/0000-0002-5708-4925)
- Roos J. Jutten (ORCID: https://orcid.org/0000-0002-3712-4790)
- Keith A. Johnson (ORCID: https://orcid.org/0000-0002-4685-5173)
- Daniel Soberanes (ORCID: https://orcid.org/0000-0001-9099-7294)
- Gad A. Marshall (ORCID: https://orcid.org/0000-0002-9096-2355)
- Onyinye J. Udeogu
- Kathryn V. Papp (ORCID: https://orcid.org/0000-0003-1687-4370)
- Dorene M. Rentz (ORCID: https://orcid.org/0000-0002-6318-9213)
- Rebecca England Amariglio (ORCID: https://orcid.org/0009-0009-5878-8930)
- Hairin Kim (ORCID: https://orcid.org/0000-0002-9623-608X)
- Lia D'Aquila
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
- Amsterdam Neuroscience (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/alz.70815
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute on Aging