Mitochondrial haplogroups, but not heteroplasmy, are associated with midlife cognitive function
Heteroplasmy burden was not associated with cognitive performance at midlife. Haplogroups were associated with cognitive outcomes at midlife. Longitudinal analysis revealed that haplogroups are associated with cognitive trajectories.
Authors
- Lifang Hou (ORCID: https://orcid.org/0000-0003-4877-0031)
- Shea J. Andrews (ORCID: https://orcid.org/0000-0002-1921-9470)
- Kristine S. Yaffe (ORCID: https://orcid.org/0000-0003-0919-3825)
- N. Yu
- Myriam Fornage
Institutions
- Northwestern University (US)
- University of California, San Francisco (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/alz.70839
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Northwestern University
- University of Minnesota
- Kaiser Foundation Research Institute
- National Institute on Aging
- National Heart, Lung, and Blood Institute