Higher vitamin B <sub>12</sub> from mid‐ to late life is related to slower rates of cognitive decline
Higher vitamin B<sub>12</sub> status is associated with slower annual cognitive decline. Higher B<sub>12</sub> was linked with 0.05 to 0.09 standard deviation less cognitive decline over 10 years. B<sub>12</sub> and memory findings are robust for elevated, not non-elevated, folate status.
Authors
- Phillip H Hwang (ORCID: https://orcid.org/0000-0001-6780-6808)
- Francesca Marino (ORCID: https://orcid.org/0000-0001-9641-052X)
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Rhoda Au (ORCID: https://orcid.org/0000-0001-7742-4491)
- Emily H. Trittschuh (ORCID: https://orcid.org/0000-0003-0557-1542)
- Andrew J. Saykin (ORCID: https://orcid.org/0000-0002-1376-8532)
- Gail Rogers (ORCID: https://orcid.org/0000-0003-0673-8092)
- Paul K. Crane (ORCID: https://orcid.org/0000-0003-4278-7465)
- Shubhabrata Mukherjee (ORCID: https://orcid.org/0000-0003-2522-2884)
- Paul F. Jacques (ORCID: https://orcid.org/0000-0001-5567-3147)
- Joshua W. Miller (ORCID: https://orcid.org/0000-0001-7638-5523)
- Jacob Selhub (ORCID: https://orcid.org/0000-0003-1103-0945)
- Jesse Mez (ORCID: https://orcid.org/0000-0003-1438-5442)
Institutions
- Rutgers, The State University of New Jersey (US)
- Boston University (US)
- Tufts University (US)
- University of Washington (US)
- VA Puget Sound Health Care System (US)
- Framingham Heart Study (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/alz.70864
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- U.S. Department of Health and Human Services
- U.S. Department of Agriculture
- Alzheimer's Association
- American Heart Association
- National Institutes of Health
- Agricultural Research Service
- National Heart, Lung, and Blood Institute
- National Institute of Diabetes and Digestive and Kidney Diseases
- U.S. National Library of Medicine