Cerebral blood flow trajectories in paediatric sickle cell anaemia by age, region, and treatment associations
Opposite to the age trend in healthy children, cerebral blood flow increases with age in children with sickle cell anaemia. Early treatment with hydroxyurea (hydroxycarbamide) may help slow this abnormal trend and protect brain functions.
Authors
- Paul S. VanGilder (ORCID: https://orcid.org/0000-0003-3066-3713)
- Andrew M. Heitzer (ORCID: https://orcid.org/0000-0003-0582-3850)
- Ranganatha Sitaram (ORCID: https://orcid.org/0000-0002-8577-8035)
- Robert J. Ogg (ORCID: https://orcid.org/0000-0003-0729-3443)
- Winfred C. Wang (ORCID: https://orcid.org/0000-0001-6774-9698)
- Akshay Sharma (ORCID: https://orcid.org/0000-0003-3281-2081)
- Zachary R. Abramson (ORCID: https://orcid.org/0000-0001-7875-1187)
- Tushar Patni (ORCID: https://orcid.org/0000-0003-1605-7207)
- Ping Zou (ORCID: https://orcid.org/0000-0002-3472-0001)
- Yimei Li (ORCID: https://orcid.org/0000-0002-7046-4316)
- Kathleen J. Helton
Institutions
- St. Jude Children's Research Hospital (US)
Publication Details
- Journal
- British Journal of Haematology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1111/bjh.70224
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00