Birefringence microscopy enables rapid, label-free quantification of myelin debris following induced cortical injury
BRM enables large-scale assessment of myelin structural alterations in post-mortem brain tissue. When combined with deep-learning object detection, BRM enables rapid quantification of myelin damage in the corpus callosum after cortical injury. With proper training, this can be extended to study structural changes in other diseases and regions such as Alzheimer's disease and chronic traumatic encephalopathy as well as normal aging.
Authors
- Rhiannon Robinson (ORCID: https://orcid.org/0000-0002-6359-7874)
- Irving J. Bigio (ORCID: https://orcid.org/0000-0003-4168-1466)
- Alexander J. Gray (ORCID: https://orcid.org/0000-0003-2536-1315)
- Douglas L. Rosene (ORCID: https://orcid.org/0000-0001-8719-1441)
- Tara L. Moore (ORCID: https://orcid.org/0000-0003-3869-3837)
- Samer A. Berghol
Institutions
- Boston University (US)
- University of Massachusetts Boston (US)
Publication Details
- Journal
- Neurophotonics
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1117/1.nph.12.4.045006
- Primary Topic
- Neurogenesis and neuroplasticity mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00