Differential molecular mechanisms of bortezomib sensitization to rhTRAIL in non-small cell lung cancer cell lines
This study underscores bortezomib's ability to differentially enhance rhTRAIL-induced apoptosis by targeting multiple apoptotic regulators. The variety of effects that bortezomib can exert to enhance rhTRAIL-induced apoptosis makes it a very powerful combination for the treatment of NSCLC and various other types of cancer cells.
Authors
- Steven de Jong (ORCID: https://orcid.org/0000-0002-0421-3041)
- Gerrit Jansen (ORCID: https://orcid.org/0000-0001-8190-8368)
- Godefridus J. Peters (ORCID: https://orcid.org/0000-0002-5447-2877)
- Frank A.E. Kruyt (ORCID: https://orcid.org/0000-0002-2445-9380)
- Leonie H.A.M. de Wilt
- Janet H. Stegehuis
- Paweł Kochany (ORCID: https://orcid.org/0000-0002-3841-6883)
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Amsterdam University Medical Centers (NL)
- Gdańsk Medical University (PL)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Exploration of Targeted Anti-tumor Therapy
- Published
- 2025-10-28
- DOI
- https://doi.org/10.37349/etat.2025.1002342
- Primary Topic
- Cell death mechanisms and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Rijksuniversiteit Groningen
- Universitair Medisch Centrum Groningen