Development and validation of an early diagnostic model to distinguish bacterial infection in patients with acute-on-chronic liver disease (AoCLD) and systemic inflammatory response syndrome (SIRS): a post-hoc analysis of a prospective multicenter co
The early diagnostic model developed in this study effectively differentiates between infectious and non-infectious SIRS in AoCLD patients, potentially reducing unnecessary antimicrobial exposure and improving clinical outcomes.
Authors
- Yubao Zheng
- Jia Shang
- Guohong Deng (ORCID: https://orcid.org/0000-0003-1263-7220)
- Ruochan Chen
- Xiaobo Lu (ORCID: https://orcid.org/0000-0001-5532-7551)
- Zhongji Meng (ORCID: https://orcid.org/0000-0003-0401-535X)
- Shiping Chen (ORCID: https://orcid.org/0000-0002-4603-0024)
- Yanhang Gao (ORCID: https://orcid.org/0000-0001-8590-6706)
- Yufang Shi (ORCID: https://orcid.org/0000-0001-8964-319X)
- Zhiping Qian
- Hai Li (ORCID: https://orcid.org/0000-0002-4762-9362)
- Xin Zheng (ORCID: https://orcid.org/0000-0003-3995-8825)
- Yan Huang (ORCID: https://orcid.org/0000-0002-1045-4044)
- Feng Liu (ORCID: https://orcid.org/0000-0001-5998-3484)
- Xianbo Wang (ORCID: https://orcid.org/0000-0003-1671-1934)
- Hui Zhou (ORCID: https://orcid.org/0000-0002-5418-8550)
Institutions
- Hubei University of Medicine (CN)
- Central South University (CN)
- Army Medical University (CN)
- Xinjiang Medical University (CN)
- Sun Yat-sen University (CN)
- Jilin University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
- European Foundation for the Study of Chronic Liver Failure (ES)
- Second Hospital of Shandong University (CN)
- Shanghai Public Health Clinical Center (CN)
- First Hospital of Jilin University (CN)
- Southwest Hospital (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Shanghai Institute of Hematology (CN)
- Beijing Ditan Hospital (CN)
- Xiangya Hospital Central South University (CN)
- Union Hospital (CN)
- Southern Medical University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.jare.2025.10.065
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00