Cutaneous Bacillary Angiomatosis: A Rare and Forgotten Infection in Immunocompromised Patient

This case describes a 50-year-old kidney transplant recipient with subacute development of erythematous-to-violaceous skin lesions on the face, trunk, and extremities, accompanied by malaise, myalgia, and arthralgia. Histopathologic analysis of skin biopsies revealed characteristic vascular proliferation consistent with bacillary angiomatosis (BA), a rare angioproliferative disease caused by <i>Bartonella</i> <i>henselae</i> or <i>Bartonella</i> <i>quintana</i> infection, primarily affecting immunocompromised individuals. The patient was treated successfully with oral doxycycline, resulting in the resolution of symptoms and lesions. BA is typically transmitted via cats and presents variably, including cutaneous angioproliferative lesions, hepatic or splenic involvement, and endocarditis. Diagnosis relies on histopathology with specialized staining and molecular testing, as culture and serologies are often insufficient. Treatment typically involves prolonged antibiotic therapy, emphasizing the importance of early recognition in immunosuppressed patients, including solid organ transplant recipients, to prevent complications.

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Publication Details

Journal
Avicenna Journal of Medicine
Published
2025-10-01
DOI
https://doi.org/10.1055/s-0045-1812318
Primary Topic
Bartonella species infections research
Type
article
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article

Cutaneous Bacillary Angiomatosis: A Rare and Forgotten Infection in Immunocompromised Patient

Emily C. Milam, Yamen Homsi, Nour Dayoub
Avicenna Journal of Medicine
Bartonella species infections research
article

Cutaneous Bacillary Angiomatosis: A Rare and Forgotten Infection in Immunocompromised Patient

Emily C. Milam, Yamen Homsi, Nour Dayoub
article en

Abstract

This case describes a 50-year-old kidney transplant recipient with subacute development of erythematous-to-violaceous skin lesions on the face, trunk, and extremities, accompanied by malaise, myalgia, and arthralgia. Histopathologic analysis of skin biopsies revealed characteristic vascular proliferation consistent with bacillary angiomatosis (BA), a rare angioproliferative disease caused by <i>Bartonella</i> <i>henselae</i> or <i>Bartonella</i> <i>quintana</i> infection, primarily affecting immunocompromised individuals. The patient was treated successfully with oral doxycycline, resulting in the resolution of symptoms and lesions. BA is typically transmitted via cats and presents variably, including cutaneous angioproliferative lesions, hepatic or splenic involvement, and endocarditis. Diagnosis relies on histopathology with specialized staining and molecular testing, as culture and serologies are often insufficient. Treatment typically involves prolonged antibiotic therapy, emphasizing the importance of early recognition in immunosuppressed patients, including solid organ transplant recipients, to prevent complications.

Avicenna Journal of MedicineVol. 15(04)
New York Hospital Queens (US), New York University (US)
Openalex Percentile: Top 68%
Bartonella species infections research
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Cutaneous Bacillary Angiomatosis: A Rare and Forgotten Infection in Immunocompromised Patient — Emily C. Milam, Yamen Homsi, et al. · Avicenna Journal of Medicine (2025) | TGRS Research Map | TGRS