RBM15 in diseases: Molecular mechanisms and clinical opportunities from RNA m6A methylation
RNA m<sup>6</sup>A methylation is the most common type of RNA modification, and RBM15 regulates various cellular processes by writing m<sup>6</sup>A methylation on RNA. m<sup>6</sup>A methylation mediated by RBM15 significantly affects RNA stability and translational efficiency, thereby regulating gene expression. In-depth studies have revealed that RBM15 affects the progression of various diseases by regulating the expression of multiple genes, and its m<sup>6</sup>A methylation modification process is also considered to be an effective therapeutic target. In this paper, we review the latest research progress on the regulation of m<sup>6</sup>A methylation modification of RBM15, its molecular regulation in various diseases, such as cancer and metabolic diseases, and the potential therapeutic drugs derived from it, with a view to providing therapeutic strategies for the subsequent research on RBM15 and gene therapy targeting RBM15.
Authors
- Qian‐Kun Ji
- Jingying Li (ORCID: https://orcid.org/0000-0003-3600-433X)
- Na Wang (ORCID: https://orcid.org/0000-0002-4578-4609)
- Junzhe Liu (ORCID: https://orcid.org/0009-0001-5118-0334)
- Zhihong Zhou
- Fengze Li
- Linzhen Huang
Institutions
- Nanchang University (CN)
- Zhoukou Normal University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Jiangxi Provincial Cancer Hospital (CN)
- Third Affiliated Hospital of Nanchang University (CN)
- Zhoukou City Academy of Agricultural Sciences (CN)
- Jiangxi Mental Health Center (CN)
Publication Details
- Journal
- Genes & Diseases
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1016/j.gendis.2025.101901
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00