First impressions count in TB
Mycobacterium tuberculosis drives expression of type I IFN-mediated neutrophil accumulation, which limits interaction between CD4 T cells and macrophages. Failure to limit type I IFN very early in the interaction between Mtb and immune cells allows rapid progression of disease (Branchett et al. https://doi.org/10.1084/jem.20250466; Gern et al. https://doi.org/10.1084/jem.20250161).
Authors
- Andrea M. Cooper (ORCID: https://orcid.org/0000-0001-6050-3863)
Institutions
- University of Leicester (GB)
Publication Details
- Journal
- The Journal of Experimental Medicine
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1084/jem.20251753
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00