Establishment of an optimized chemotherapy-induced mouse model for premature ovarian failure: protocol and findings
These results suggest that the single dose IP injection of the CTX 100 mg/kg + Bu 20 mg/kg can effectively induce POF within 3 weeks post-administration and POF model maintains for at least 3 weeks after induction.
Authors
- Narges Zaeemzadeh
- Tayebeh Rastegar (ORCID: https://orcid.org/0000-0002-6515-9974)
- Behrouz Gharesi‐Fard (ORCID: https://orcid.org/0000-0002-0162-3395)
- Negar Yavari
- Negar Ajabi Ardehjani
- Fardin Amidi (ORCID: https://orcid.org/0000-0003-1453-6191)
Institutions
- Shiraz University of Medical Sciences (IR)
- Guilan University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Aging
- Published
- 2025-10-28
- DOI
- https://doi.org/10.18632/aging.206332
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tehran University of Medical Sciences and Health Services