LDLRAD4 is a potential diagnostic and prognostic biomarker correlated with immune infiltration in myelodysplastic syndromes
We conclude that LDLRAD4, FAM43A, and KCNK5 are potential biomarkers for MDS. LDLRAD4's overexpression <i>in vitro</i> inhibits MDS cell proliferation and promotes apoptosis, suggesting significant potential for immunotherapy research. These findings collectively identify LDLRAD4 as a promising therapeutic target for MDS. However, its clinical applicability warrants further investigation to validate its potential.
Authors
- Honghua He (ORCID: https://orcid.org/0000-0002-5785-2242)
- Lirong Nie
- Kaixiang Zhang (ORCID: https://orcid.org/0000-0002-6812-6342)
- Jihong Zhong (ORCID: https://orcid.org/0000-0002-6281-470X)
- Shihao Wu (ORCID: https://orcid.org/0000-0002-3360-1633)
- Qing Li (ORCID: https://orcid.org/0000-0002-7930-2145)
- Yuming Zhang (ORCID: https://orcid.org/0000-0003-2293-9601)
- Mengjie Xu
Institutions
- Guangdong Medical College (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-10-28
- DOI
- https://doi.org/10.3389/fgene.2025.1540161
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00