Determination of the chemical content of Sphagnum molle and its antiproliferative activity

For the first time, this study presents the phytochemical and anticancer activity studies on Sphagnum molle species. Chemical component analysis of S. molle plant was carried out by HPLC/TOF-MS. Anticancer activity studies of its organic solvent extract against human prostate cancer (PC3) cells were performed. Chlorogenic acid, along with gentisic, 4-hydroxy-benzoic, protocatechic, vanillic, chicoric, ferulic, and cinnamic acids, 4-hydroxybenzaldehyde, and rutin, were identified as the main components in S. molle extract. In the antiproliferative activity studies of MeOH:CHCl3 extract of S. molle plant, high dose was found to show the highest activity against human prostate cancer (PC3) cells with a 68% inhibition between the 10th and 15th hours.