Antimicrobial activity of ozonated sunflower oil against Pseudomonas aeruginosa strains isolated from mares, and interactions with antimicrobial drugs

Infectious endometritis in mares can result in reduced fertility, early embryonic loss, and general health decline, implicating extensive economic loss. Pseudomonas aeruginosa is an opportunistic pathogen that is among the most frequent bacterial pathogens associated with infectious endometritis in mares. Here we explored the antimicrobial potential of ozonated sunflower seed oil, compared to the conventional form (both widely explored for wound healing), against clinical isolates of Pseudomonas aeruginosa obtained from mares with endometritis. The effects of combining the oils with clinically relevant antimicrobial drugs were also investigated. The conventional form of the oil was active against the strains, whereas the ozonated oil was not. When combined with the antimicrobials, both oils significantly decreased the pharmacological activity of the drugs. This study opens doors for discussions on clinical protocols for treating fertility issues in mares, as well as bacterial resistance in the intrauterine environment.