Intra-arrest therapeutic hypothermia with combined helium-mixed gas and cold fluid infusion significantly augments brain cooling efficiency: An experimental study in pigs

The IATH method with IALC using a helium gas mixture and cold fluid infusion rapidly decreased brain temperature by approximately 0.8 °C within 10 min after the start of resuscitation. CMD with IATH showed no increase in glutamate levels, suggesting a possible cerebroprotective effect, and cardiac resuscitation could be performed without complications. These facts suggest that this IATH method of rapidly decreasing brain temperature may be more effective for mitigating post-CA brain injury.