Artificial Intelligence and Multimodality Data Integration Decipher Tertiary Lymphoid Structure Maturity in Gastric Cancer
A deep learning model demonstrates that higher tertiary lymphoid structure maturity predicts improved gastric cancer patient survival and identifies a key immune circuit, offering a clinically applicable tool that could guide treatment. This article is part of a special series: Driving Cancer Discoveries with Computational Research, Data Science, and Machine Learning/AI.
Authors
- Jia Qi (ORCID: https://orcid.org/0000-0001-8439-4454)
- Wenxuan Wu (ORCID: https://orcid.org/0009-0005-9627-4202)
- Yikai Luo (ORCID: https://orcid.org/0000-0001-7589-7981)
- Yuan Ding (ORCID: https://orcid.org/0009-0001-4948-3563)
- Kai Song (ORCID: https://orcid.org/0000-0003-1807-9688)
- Xiaying Han (ORCID: https://orcid.org/0009-0008-3870-6734)
- Shaojun Yu (ORCID: https://orcid.org/0000-0003-4480-971X)
- Xiaoli Jin (ORCID: https://orcid.org/0000-0002-2520-0020)
- Zhenzhen Xun (ORCID: https://orcid.org/0009-0007-3667-9771)
- Han Liang (ORCID: https://orcid.org/0000-0001-7633-286X)
- Qimiao Chen (ORCID: https://orcid.org/0009-0006-7981-9650)
- Can Hu (ORCID: https://orcid.org/0000-0002-8687-8310)
- Xiangdong Cheng (ORCID: https://orcid.org/0000-0002-5099-490X)
- Pin Wu (ORCID: https://orcid.org/0000-0002-0472-1425)
- Yaxuan Han (ORCID: https://orcid.org/0009-0005-0100-0058)
- Jian Chen (ORCID: https://orcid.org/0000-0002-2542-9669)
- Lie Wang (ORCID: https://orcid.org/0000-0001-5094-012X)
- Xiaojing Ma (ORCID: https://orcid.org/0000-0003-1933-0280)
- Yewei Xu (ORCID: https://orcid.org/0009-0003-5003-3038)
- Zhiqiang Zhu (ORCID: https://orcid.org/0000-0003-4329-1154)
- Guofeng Chen (ORCID: https://orcid.org/0000-0003-1927-088X)
- Zhixing Hao (ORCID: https://orcid.org/0009-0004-9976-1615)
- Jing Chen (ORCID: https://orcid.org/0009-0001-5425-7085)
- Muxing Kang (ORCID: https://orcid.org/0000-0001-6743-5541)
- Yongyuan Yhen (ORCID: https://orcid.org/0009-0005-2243-8438)
Institutions
- University of Science and Technology of China (CN)
- The University of Texas MD Anderson Cancer Center (US)
- Sun Yat-sen University (CN)
- University of California, San Francisco (US)
- Zhejiang Cancer Hospital (CN)
- Zhejiang Lab (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1158/0008-5472.can-25-1793
- Citations
- 3
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 4.56