Integrated Single-Nucleus and Spatial Transcriptomics Elucidate Heterogeneity and Hypoxia-Driven Organization of Supratentorial Ependymoma
The characterization of transcriptional and spatial heterogeneity in supratentorial ependymoma provides a resource that can inform investigations into potential targets for therapeutic interventions aimed at tumor cells within distinct microenvironments.
Authors
- Martin Ebinger (ORCID: https://orcid.org/0000-0002-4229-8058)
- Thomas Albert (ORCID: https://orcid.org/0000-0002-2488-0706)
- Claudia Rössig (ORCID: https://orcid.org/0000-0002-8672-5285)
- Julia Bothe (ORCID: https://orcid.org/0009-0000-3723-9240)
- Lea Altendorf (ORCID: https://orcid.org/0009-0002-9426-6944)
- Christian Thomas (ORCID: https://orcid.org/0000-0002-6642-7774)
- Dorothee Cäcilia Spille (ORCID: https://orcid.org/0000-0001-8358-1848)
- Tobias Blau (ORCID: https://orcid.org/0000-0003-0439-971X)
- Kornelius Kerl (ORCID: https://orcid.org/0000-0002-5676-8102)
- W. Stummer (ORCID: https://orcid.org/0009-0003-9103-2357)
- Jens Schittenhelm (ORCID: https://orcid.org/0000-0002-9168-6209)
- Flavia W. de Faria (ORCID: https://orcid.org/0000-0003-0162-6331)
- Camelia‐Maria Monoranu (ORCID: https://orcid.org/0000-0002-1345-7363)
- Clara Inserte (ORCID: https://orcid.org/0000-0001-7371-8839)
- I‐Na Lu (ORCID: https://orcid.org/0000-0002-3845-7386)
- Ulrich Schüller (ORCID: https://orcid.org/0000-0002-8731-1121)
- Angela Brentrup (ORCID: https://orcid.org/0009-0008-7703-2007)
- Stephan Tippelt (ORCID: https://orcid.org/0000-0001-8791-9914)
- David Gorodezki (ORCID: https://orcid.org/0000-0002-7311-5840)
- Erik Schüftan (ORCID: https://orcid.org/0009-0007-2093-1020)
- Ann-Katrin Bruns (ORCID: https://orcid.org/0009-0002-2778-0978)
- Adrienn Bagosi (ORCID: https://orcid.org/0009-0005-4834-2143)
Institutions
- Universität Hamburg (DE)
- University of Münster (DE)
- Universitätsklinikum Tübingen (DE)
- University Hospital Münster (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Kinderkrebs-Zentrum Hamburg (DE)
- Essen University Hospital (DE)
- University Children's Hospital Tübingen (DE)
- Universitätsklinikum Würzburg (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1158/0008-5472.can-25-2694
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00