Large-Scale T-cell Receptor Repertoire Profiling Unveils Tumor-Specific Signals for Diagnosing Indeterminate Pulmonary Nodules
Construction of the largest TCR database of lung nodules enabled identification of lung cancer-specific TCR sequences and development of an advanced machine learning model to distinguish benign from malignant pulmonary nodules. This article is part of a special series: Driving Cancer Discoveries with Computational Research, Data Science, and Machine Learning/AI .
Authors
- Shifu Chen (ORCID: https://orcid.org/0000-0001-5799-653X)
- Tao Yue (ORCID: https://orcid.org/0000-0002-7500-1433)
- An‐Yuan Guo (ORCID: https://orcid.org/0000-0002-5099-7465)
- Jian Hua Huang (ORCID: https://orcid.org/0000-0003-3282-8892)
- Jieke Liu (ORCID: https://orcid.org/0000-0001-5448-9479)
- Shuxiong Zhou (ORCID: https://orcid.org/0009-0002-1615-9844)
- Huaichao Luo (ORCID: https://orcid.org/0000-0002-8632-5230)
- Xiaoni Zhang (ORCID: https://orcid.org/0000-0002-2535-6500)
- Peng Zhou (ORCID: https://orcid.org/0000-0002-1281-6088)
- Xinyu Luan (ORCID: https://orcid.org/0009-0001-2366-5131)
- Ruiling Zu (ORCID: https://orcid.org/0000-0002-9803-1459)
- Peiying Zhang (ORCID: https://orcid.org/0009-0008-7805-8380)
- Run Xiang (ORCID: https://orcid.org/0000-0002-2565-3783)
- Junbin Wang (ORCID: https://orcid.org/0000-0003-4480-5700)
- Qun Yi (ORCID: https://orcid.org/0009-0007-2136-0354)
- Yaru Chen (ORCID: https://orcid.org/0009-0009-0483-740X)
- Wenjian Qin (ORCID: https://orcid.org/0000-0003-2547-0394)
- Xing Yin (ORCID: https://orcid.org/0009-0006-2014-5794)
- Zhicheng Li (ORCID: https://orcid.org/0000-0003-4140-0580)
- Wei Guo (ORCID: https://orcid.org/0000-0001-5294-5047)
- Xiaoqin Liu (ORCID: https://orcid.org/0009-0003-9725-0750)
- Jia Gu (ORCID: https://orcid.org/0000-0001-7498-9892)
- Mingyan Xu (ORCID: https://orcid.org/0000-0002-0680-7775)
- Dongsheng Wang (ORCID: https://orcid.org/0000-0003-1241-4908)
- Bin Hu (ORCID: https://orcid.org/0000-0002-7609-8222)
- Jixian Liu (ORCID: https://orcid.org/0000-0001-6184-6905)
- Xin Yang (ORCID: https://orcid.org/0009-0003-3319-5094)
- Lubei Rao (ORCID: https://orcid.org/0000-0002-8243-0076)
- Sisi Yu (ORCID: https://orcid.org/0009-0002-4728-0241)
Institutions
- University of Electronic Science and Technology of China (CN)
- Sichuan University (CN)
- Shenzhen Bioeasy Biotechnology (China) (CN)
- West China Hospital of Sichuan University (CN)
- Shenzhen Sixth People's Hospital (CN)
- Gannan Medical University (CN)
- Sichuan Cancer Hospital (CN)
- Beike Biotechnology (China) (CN)
- Peking University Shenzhen Hospital (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- City University of Macau (MO)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1158/0008-5472.can-25-1407
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05