Vinculin mediates a dynamic signal flow underlying cardiac outflow tract development as revealed by single-cell and spatial transcriptomic analysis
In sum, dynamic signal flows among CNCC and SHF cells guide OFT remodeling, in which p38-Tgf-β signaling mediates the VSMC lineage differentiation of CNCCs, and timely regulates their interactions with SHF-derived cells through ECM.
Authors
- Chi‐chung Hui (ORCID: https://orcid.org/0000-0001-7047-6694)
- Kyoung-Han Kim (ORCID: https://orcid.org/0000-0002-0433-656X)
- Esw Ngan (ORCID: https://orcid.org/0000-0002-0022-7999)
- Asif Javed (ORCID: https://orcid.org/0000-0002-6945-9624)
- Reeson Xu Wang (ORCID: https://orcid.org/0000-0001-8458-0599)
- Xixin Wang (ORCID: https://orcid.org/0000-0002-1648-2820)
- Zhixin Li (ORCID: https://orcid.org/0000-0001-9962-3942)
- Yan Pan (ORCID: https://orcid.org/0009-0003-3713-8329)
- Mingxuan Liang (ORCID: https://orcid.org/0009-0003-8892-8953)
Institutions
- University of Ottawa (CA)
- Hospital for Sick Children (CA)
- HKU-Pasteur Research Pole (HK)
- University of Hong Kong (HK)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.jare.2025.10.062
- Citations
- 1
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 0.81