Phage Henu12-resistant mutant derives fitness trade-offs in <i>Shigella dysenteriae</i>
Phage therapy is a promising approach to combat the rise of multidrug-resistant bacteria. The emergence of phage-resistant bacterial strains is a potential complication associated with the application of phages. In the current study, we demonstrated that the synergistic use of phage Henu12 in conjunction with antibiotics not only enhances the bactericidal efficacy but also postpones the development of resistant strains. In addition, we provide a better understanding of the fitness trade-off that might fill some gaps in the future success of phage therapies in combating resistant shigellosis in clinical settings.
Authors
- Salwa E. Gomaa (ORCID: https://orcid.org/0000-0002-7772-7326)
- Jie Shen (ORCID: https://orcid.org/0000-0002-6021-7151)
- Yuanrong Tu (ORCID: https://orcid.org/0009-0005-1449-4675)
- Na Chen (ORCID: https://orcid.org/0009-0002-4798-8493)
- Xiaotao Dong (ORCID: https://orcid.org/0009-0006-2086-1563)
- Huiru Cao (ORCID: https://orcid.org/0000-0002-7652-8982)
- Yvjie Wang (ORCID: https://orcid.org/0009-0008-9160-2352)
- Qiming Li (ORCID: https://orcid.org/0000-0002-6916-3954)
- Zuan Yan (ORCID: https://orcid.org/0000-0003-3768-5819)
- Yulu Du (ORCID: https://orcid.org/0009-0001-7506-7045)
- Jingjing Li (ORCID: https://orcid.org/0009-0008-1045-0810)
- Jing Zhao (ORCID: https://orcid.org/0009-0008-4943-3196)
- Yangyang Liu (ORCID: https://orcid.org/0009-0003-8157-9500)
- Xin-Ying Ji (ORCID: https://orcid.org/0009-0000-0963-1368)
- Tieshan Teng (ORCID: https://orcid.org/0009-0007-3848-3369)
Institutions
- Henan University (CN)
- Zagazig University (EG)
- Henan Provincial Institute of Occupational Health (CN)
- Henan University Huaihe Hospital and Huaihe Clinical Institute (CN)
- Huaian First People’s Hospital (CN)
- The People's Hospital of LinXia (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1128/spectrum.01150-25
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00