Evaluation of Endothelial Glycocalyx Damage in Neonatal Lambs With Diarrhoea: A Biomarker‐Based Approach
Lambs with diarrhoea showed significantly higher total leukocyte (white blood cell [WBC]), granulocyte (GRA) and monocyte (MON) counts (p < 0.01). Serum NO concentrations were significantly elevated in lambs with diarrhoea, whereas HS and Ang-2 concentrations were lower (p < 0.01). E. coli-infected lambs had significantly higher ADAM15 concentrations than those with Cryptosporidium infection (p < 0.001). These findings suggest that NO may have a protective and/or anti-inflammatory role in neonatal lamb diarrhoea, potentially maintaining eGC integrity despite the inflammatory process.
Authors
- Merve İder (ORCID: https://orcid.org/0000-0003-2928-5452)
- Tuğba Melike Parlak (ORCID: https://orcid.org/0000-0003-3277-0336)
- Murat Kaan Durgut (ORCID: https://orcid.org/0000-0002-4582-8536)
- Mahmut Ok (ORCID: https://orcid.org/0000-0002-8210-6735)
- Bünyamin Traş (ORCID: https://orcid.org/0000-0001-9122-8059)
- Süleyman Serhat İyigün (ORCID: https://orcid.org/0000-0002-3270-1931)
- Amir Naseri (ORCID: https://orcid.org/0000-0001-9140-5879)
- Abdulrahman Alhallaq (ORCID: https://orcid.org/0000-0002-2307-1907)
Institutions
- Selçuk University (TR)
Publication Details
- Journal
- Veterinary Medicine and Science
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1002/vms3.70621
- Primary Topic
- Animal health and immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00