Psychometric Properties and Interpretability of PRO-CTCAE® Average Composite Scores as a Summary Metric of Symptomatic Adverse Event Burden
The ACS demonstrated structural validity through adequately fitting linear factor models and effectively summarized symptomatic AE burden. However, similar ACS values may mask clinically distinct symptomatic AE profiles, underscoring the value of both summary metrics and profile-based approaches.
Authors
- Brenda Ginos
- Sandra A. Mitchell (ORCID: https://orcid.org/0000-0002-4153-9972)
- Lauren Rogak (ORCID: https://orcid.org/0009-0009-9430-2256)
- Minji K. Lee (ORCID: https://orcid.org/0000-0002-1301-4319)
- Tito R. Mendoza (ORCID: https://orcid.org/0000-0001-8122-5233)
- Antonia V. Bennett (ORCID: https://orcid.org/0000-0002-8968-4511)
- Blake Langlais
- Brie N. Noble (ORCID: https://orcid.org/0000-0001-5144-1154)
- Gina L. Mazza (ORCID: https://orcid.org/0000-0002-5305-6193)
- Allison Mary Deal (ORCID: https://orcid.org/0000-0003-3526-3938)
- Gita Thanarajasingam (ORCID: https://orcid.org/0000-0003-2144-5415)
- Amylou Constance Dueck (ORCID: https://orcid.org/0000-0002-9912-1085)
- Ethan Basch (ORCID: https://orcid.org/0000-0003-3813-9318)
Institutions
- University of North Carolina at Chapel Hill (US)
- Mayo Clinic (US)
- WinnMed (US)
- Mayo Clinic in Arizona (US)
- National Cancer Institute (MY)
- National Cancer Institute (US)
- Mayo Clinic in Florida (US)
- UNC Lineberger Comprehensive Cancer Center
Publication Details
- Journal
- Cancers
- Published
- 2025-10-28
- DOI
- https://doi.org/10.3390/cancers17213459
- Citations
- 1
- Primary Topic
- Traumatic Brain Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 1.35