Scorpion Venom Heat-Resistant Synthetic Peptide Alleviates DSS-Induced Colitis via α7nAChR-Mediated Modulation of the JAK2/STAT3 Pathway
These results demonstrated that SVHRSP alleviated intestinal inflammation via α7nAChR-dependent JAK2/STAT3 activation. Combined with its known neuroprotective properties, our findings support the repurposing of this neuroactive peptide, SVHRSP, for treating intestinal inflammatory disorders.
Authors
- Guo‐Wei He (ORCID: https://orcid.org/0000-0001-6497-876X)
- Xiaolin Cui
- Jau‐Shyong Hong (ORCID: https://orcid.org/0000-0002-3056-8401)
- Xiaxia Li
- Yuqian Li
- Kang Cheng (ORCID: https://orcid.org/0000-0002-3114-271X)
- Li Sheng (ORCID: https://orcid.org/0000-0002-6649-2840)
- Yanjie Guo (ORCID: https://orcid.org/0000-0001-8299-128X)
- Jie Zhao (ORCID: https://orcid.org/0000-0003-3760-4038)
- Xuefei Wu
Institutions
- Dalian Medical University (CN)
- National Institute of Environmental Health Sciences (US)
Publication Details
- Journal
- Antioxidants
- Published
- 2025-10-28
- DOI
- https://doi.org/10.3390/antiox14111296
- Primary Topic
- Neuropeptides and Animal Physiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00