<i>ALDH2</i> rs671 variant enhances platelet activation and thrombosis by disrupting mitochondrial complex I assembly
The ALDH2 rs671 variant enhances collagen-induced platelet activation and thrombosis by impairing mitochondrial complex I assembly and function. NAD+ supplementation offers a promising strategy to mitigate thrombotic risk in individuals carrying this variant.
Authors
- Aijun Sun (ORCID: https://orcid.org/0000-0003-1488-0937)
- Wenting Zhou (ORCID: https://orcid.org/0000-0002-4360-1231)
- Liping Han (ORCID: https://orcid.org/0000-0001-6380-2105)
- Xiaolei Sun (ORCID: https://orcid.org/0000-0002-5260-379X)
- Zhihan Chen (ORCID: https://orcid.org/0000-0002-4279-4553)
- Haoxuan Zhong (ORCID: https://orcid.org/0000-0001-5038-299X)
- Maieryemu Waresi
- Hongyi Wu
- Peng Zhang
- Wei Zhang (ORCID: https://orcid.org/0000-0002-9601-4823)
- Junbo Ge (ORCID: https://orcid.org/0000-0002-9360-7332)
- Si Zhang (ORCID: https://orcid.org/0000-0002-5682-4995)
- Zhiyong Qi (ORCID: https://orcid.org/0000-0001-5720-4061)
- Luning Zhou (ORCID: https://orcid.org/0000-0001-5283-4769)
- Huajie Xu
Institutions
- Shanghai Medical College of Fudan University (CN)
- Sun Yat-sen University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University (CN)
- National Clinical Research (US)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1093/cvr/cvaf194
- Citations
- 1
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.77