Concomitant use of direct oral anticoagulants and interacting antiarrhythmic drugs and the risk of stroke and bleeding among patients with non-valvular atrial fibrillation: a multinational cohort study
Concomitant use of interacting antiarrhythmic drugs does not seem to affect the effectiveness of DOACs but may increase their risk of major bleeding.
Authors
- Jenny Dimakos
- Fabian Maximilian Meinert (ORCID: https://orcid.org/0000-0002-5168-5316)
- Kristian B. Filion (ORCID: https://orcid.org/0000-0001-6055-0088)
- Christel Renoux (ORCID: https://orcid.org/0000-0002-4691-9579)
- Antonios Douros (ORCID: https://orcid.org/0000-0002-6005-4006)
- Ying Cui (ORCID: https://orcid.org/0000-0003-4917-0919)
Institutions
- McGill University Health Centre (CA)
- Jewish General Hospital (CA)
- McGill University (CA)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1186/s12916-025-04464-6
- Citations
- 1
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- McGill University
- Deutsche Forschungsgemeinschaft