Diffuse midline glioma, H3K27-altered, mimicking central neurocytoma on MRI: A case report
Diffuse midline glioma (DMG), H3K27-altered, is an aggressive central nervous system tumor that usually arises in midline structures such as the pons, thalamus, or spinal cord. We present a rare case of intraventricular DMG, H3K27-altered in a 35-year-old woman. MRI showed a soap-bubble appearance, initially suggestive of central neurocytoma, but histopathological and immunohistochemical analyses confirmed the final diagnosis of DMG, H3K27-altered. This is the first reported intraventricular DMG, H3K27-altered with a soap-bubble appearance, underscoring the importance of including this tumor in the differential diagnosis of intraventricular masses.
Authors
- Takamichi Murakami (ORCID: https://orcid.org/0000-0001-7782-548X)
- Takashi Sasayama (ORCID: https://orcid.org/0000-0002-5593-9045)
- Naoe Jimbo (ORCID: https://orcid.org/0000-0003-0423-3568)
- Tomonori Kanda (ORCID: https://orcid.org/0000-0003-2719-8283)
- Tatsuhiko Miyazaki (ORCID: https://orcid.org/0000-0002-4750-2046)
- Shiho Yokoo
- Yasuyuki Kojita (ORCID: https://orcid.org/0000-0002-1152-7487)
- Kazuki Yasuda (ORCID: https://orcid.org/0000-0002-6966-496X)
- Feiya Zeng (ORCID: https://orcid.org/0009-0007-8053-7498)
Institutions
- Kobe University (JP)
Publication Details
- Journal
- Radiology Case Reports
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1016/j.radcr.2025.09.074
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00