Cellular interactions and gene expression analysis of two equine-derived bone graft materials: an in vitro study

Our results suggest that both hydrolyzed and preserved type I collagen support bone matrix deposition more effectively than β-tricalcium phosphate, with preserved collagen demonstrating superior performance. From a clinical perspective, preserved collagen appears to be the optimal choice for larger or less contained bone defects, as it promotes faster cell repopulation and may lead to more rapid remodeling with the patient's own vital bone. In contrast, hydrolyzed collagen seems to elicit a slower cellular response and may be better suited for smaller, localized defects where immediate biological activity is less critical. Further research is essential to guide clinicians in selecting the most appropriate bone graft substitute based on the specific clinical context.

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Publication Details

Journal
Minerva Dental and Oral Science
Published
2025-10-28
DOI
https://doi.org/10.23736/s2724-6329.25.05209-x
Primary Topic
Bone Tissue Engineering Materials
Type
article
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article

Cellular interactions and gene expression analysis of two equine-derived bone graft materials: an in vitro study

Francesco Orlando, Christian Frigerio, Anna Di Bona, Domenico Recupero et al.
Minerva Dental and Oral Science
Bone Tissue Engineering Materials
article

Cellular interactions and gene expression analysis of two equine-derived bone graft materials: an in vitro study

Francesco Orlando, Christian Frigerio, Anna Di Bona, Domenico Recupero, Francesca Ruffini, Paola Panina‐Bordignon, Valentina Murtaj, M. Morroni, Matteo Colombo, Danilo Alessio Di Stefano, E. Brambilla, Enrico Felice Gherlone, Luca Coccoluto
article en

Abstract

Our results suggest that both hydrolyzed and preserved type I collagen support bone matrix deposition more effectively than β-tricalcium phosphate, with preserved collagen demonstrating superior performance. From a clinical perspective, preserved collagen appears to be the optimal choice for larger or less contained bone defects, as it promotes faster cell repopulation and may lead to more rapid remodeling with the patient's own vital bone. In contrast, hydrolyzed collagen seems to elicit a slower cellular response and may be better suited for smaller, localized defects where immediate biological activity is less critical. Further research is essential to guide clinicians in selecting the most appropriate bone graft substitute based on the specific clinical context.

Minerva Dental and Oral ScienceVol. 74(6)
Vita-Salute San Raffaele University (IT), Azienda Industriali Municipali di Vicenza (Italy) (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT), Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT), National Center for Genetic Engineering and Biotechnology (TH)
Openalex Percentile: Top 70%
Bone Tissue Engineering Materials
DOIOpen Access PDFOpenAlex
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Cellular interactions and gene expression analysis of two equine-derived bone graft materials: an in vitro study — Francesco Orlando, Christian Frigerio, et al. · Minerva Dental and Oral Science (2025) | TGRS Research Map | TGRS