Targeting focal adhesion kinase inhibits cell migration and non-angiogenic vascularization in malignant breast cancer
FAK inhibition was shown to suppress non-angiogenic vascularization. Defactinib has the potential to serve as a novel treatment for malignant breast cancer which is resistant to conventional therapies.
Authors
- Tomonori Tanei (ORCID: https://orcid.org/0000-0003-2183-8681)
- Masafumi Shimoda (ORCID: https://orcid.org/0000-0002-0832-9877)
- Chieko Mishima
- Yoshiaki Sota (ORCID: https://orcid.org/0000-0001-5963-652X)
- Nanae Masunaga (ORCID: https://orcid.org/0000-0002-6164-5107)
- Tomohiro Miyake (ORCID: https://orcid.org/0000-0002-9362-9822)
- Kaori Abe (ORCID: https://orcid.org/0009-0000-8849-5711)
- Tetsuhiro Yoshinami (ORCID: https://orcid.org/0009-0000-8747-3641)
- Masami Tsukabe (ORCID: https://orcid.org/0009-0009-3284-0833)
- Misato Masuyama (ORCID: https://orcid.org/0009-0008-0873-4486)
- Ichiro Seto (ORCID: https://orcid.org/0000-0002-9406-5440)
- Kaori Kikumori
- Kenzo Shimazu (ORCID: https://orcid.org/0000-0002-0837-2357)
Institutions
- The University of Osaka (JP)
Publication Details
- Journal
- Breast Cancer
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1007/s12282-025-01792-6
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science